Jin-Roh is set in an alternate universe where, in Tokyo of the 1950s, advanced technology already abounds. A totalitarian government is ruthlessly crushing dissident activists. Our protagonist is Kazuki Fuse, a member of the Kerberos, a heavily armed Special Unit trained to crush resistance. While on a mission to eliminate the members of an anti-government group hiding in the sewer system, he corners a young member of The Sect. Forced to gun the girl down before she detonates a bomb, Fuse is haunted by her death. A near nervous collapse and an obsessive search ironically leads him to her sister, with whom he begins an unlikely relationship— both of them sharing the same loneliness and despair. Behind the girl's innocence lurks a plot more complex than Fuse could have imagined, a scheme woven by a shadowy vigilante force known as Jin-Roh (The Wolf Brigade).