Sometimes it takes a trauma to change things for the better.

An inner-urban Melbourne family is turned upside down when their young son Jack is diagnosed with leukemia, and his father's years of infidelity come to light. As the illness takes hold, a desperate mother searches for possible siblings from her husband's affairs - children who may hold the key to curing her son.

From filmmakers Nadia Tass and David Parker - the team that brought us Malcolm, The Big Steal and Amy - comes a story of love and pain, despair and hope. Matching Jack is a tale of real issues affecting families, and how humour and optimism guide a mother through her darkest hours.

Features James Nesbitt, Richard Roxburgh, Jacinda Barrett, Colin Friels, Yvonne Strahovski, Tom Russell and Kodi Smit McPhee.