Science's newest miracle is a big, big mistake.

Almost a century after Frankenstein's monster first lumbered across cinema screens, Splice proves the ‘humans as God' horror genre never goes out of fashion.

With the support of executive producer Guillermo Del Toro and the influence of Canadian ‘body horror' compatriot David Cronenberg, filmmaker Vincenzo Natali (Cube) wrangles his biggest budget yet to concoct something totally unpredictable.

Adrien Brody and Sarah Polley play superstar genetic engineers who add human DNA to their latest hybrid. The result is a creature with a startling amalgamation of limbs, a growth rate that's off the chart, and a range of needs of its own.

“Splice explores our relationship to technology and the doors it unlocks. It pushes us to places we're unable, or afraid, to go.” - filmmaker Vincenzo Natali